Variability of High-Sensitivity Troponin T Concentrations in Emergency Settings

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Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction.

OBJECTIVES This study sought to evaluate if an undetectable (<5 ng/l) high-sensitivity cardiac troponin T (hs-cTnT) level and an electrocardiogram (ECG) without signs of ischemia can rule out myocardial infarction (MI) in the emergency department (ED). BACKGROUND Chest pain is a common symptom often associated with benign conditions, but may be a sign of MI. Because there is no rapid way to r...

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Defining high-sensitivity cardiac troponin concentrations in the community.

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High-sensitivity troponin T concentrations in acute chest pain patients evaluated with cardiac computed tomography.

BACKGROUND For evaluation of patients with chest pain and suspected acute coronary syndrome (ACS), consensus guidelines recommend use of a cardiac troponin cut point that corresponds to the 99 th percentile of a healthy population. Most conventional troponin methods lack sufficient precision at this low level. METHODS AND RESULTS In a cross-sectional study, 377 patients (mean age 53.7 years, ...

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Imaging High-Sensitivity Troponin T Concentrations in Acute Chest Pain Patients Evaluated With Cardiac Computed Tomography

Background—For evaluation of patients with chest pain and suspected acute coronary syndrome (ACS), consensus guidelines recommend use of a cardiac troponin cut point that corresponds to the 99th percentile of a healthy population. Most conventional troponin methods lack sufficient precision at this low level. Methods and Results—In a cross-sectional study, 377 patients (mean age 53.7 years, 64....

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Biological and analytical variability of a novel high-sensitivity cardiac troponin T assay.

BACKGROUND High-sensitivity cardiac troponin assays will augment the frequency of increased results, making important the determination of reference change values to distinguish acute from chronic increases. We assessed short- and long-term biological variability of cardiac troponin T (cTnT) in healthy subjects with a novel high-sensitivity (hs) assay. METHODS We collected blood from 20 healt...

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ژورنال

عنوان ژورنال: American Journal of Clinical Pathology

سال: 2018

ISSN: 0002-9173,1943-7722

DOI: 10.1093/ajcp/aqy025